tag:blogger.com,1999:blog-4893234962600967689.post6186916929041459250..comments2023-09-02T06:44:22.702-07:00Comments on Wildly Fluctuating: Stupid Fat StudyGretchenhttp://www.blogger.com/profile/17019921800841883073noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-4893234962600967689.post-11022547956299115572010-05-29T22:10:54.370-07:002010-05-29T22:10:54.370-07:00I'm sad to see that it was performed at one of...I'm sad to see that it was performed at one of our Aussie universities. Here is the abstract; the method looks a little more intelligent but they still come to the same absurd conclusions.<br /><br />A High Fat, High Energy Food Challenge Induces an Exaggerated Inflammatory Response in Asthma.<br /><br />http://ajrccm.atsjournals.org/cgi/reprint/179/1_MeetingAbstracts/A2186.pdf<br /><br />"Rationale: Dietary fat has been shown to activate the innate immune response, which is known to contribute to the development or worsening of asthma in some individuals. The aim of this study was to examine the effect of dietary fat on innate immune responses in asthma.<br />Methods: Non−obese (BMI <30) subjects with asthma were randomized to receive a high fat/high energy (AHiFHE) (n=8) or low fat/ low energy (ALoFLE) (n=10) food challenge. Non−obese healthy controls (n=10) also underwent a high fat/ high energy (CHiFHE) food challenge. Subjects on the AHiFHE and CHiFHE challenge consumed 200% daily energy requirement in 24 hours, including 50% energy from fat. Subjects on the ALoFLE challenge consumed 75% daily energy requirement in 24 hours, including 20% energy from fat. Clinical assessment and blood samples were collected at 0, 2, 3, 4 and 24 hours. Inflammatory markers, including plasma TNFa, CRP and IL−6, were analysed by high sensitivity ELISAs.<br />Results: At 4 hours after the commencement of the food challenges, subjects on the AHiFHE challenge, had a significantly higher increase in plasma CRP concentrations, compared to subjects on both the ALoFLE and CHiFHE challenge (p= 0.021).<br />The AHiFHE challenge resulted in a significantly higher increase in plasma TNFa concentration at 3 hours, compared to the ALoFLE challenge (p = 0.034).<br />Conclusion: A high fat/ high energy intake causes an exaggerated increase in systemic inflammation in subjects" <br /><br />Possibly the full text may make more sense, but I doubt it.<br /><br />I don't give scientists the benefit of the doubt; I only give them the benefit of my time to read their paper. If it looks half way intelligent I may give them the benefit of a little more time (actually, sometimes a LOT more time :)) to try to understand it.Alanhttps://www.blogger.com/profile/02868809225921579099noreply@blogger.comtag:blogger.com,1999:blog-4893234962600967689.post-40819827759257740062010-05-17T11:53:28.475-07:002010-05-17T11:53:28.475-07:00I haven't seen the study, but it sounds like t...I haven't seen the study, but it sounds like the same "stupid" interpretation that goes on with so many studies. They see what they want to see; what maintains the status quo. Big sigh. Thanks for posting about this.Michellehttps://www.blogger.com/profile/01805403370463885686noreply@blogger.com