Friday, August 31, 2018

Are low-carb diets dangerous?

The popular press is having a field day with this studywith headlines like "Is your low-carb diet killing you?"

Well, my exhaustive analysis is as follows:


If you want more details, Zoe Harcomb has done a thorough review.

Tuesday, August 28, 2018


When I was diagnosed with type 2 diabetes in 1996, the number of artificial sweeteners was limited. There was saccharin, of course, which had been discovered in 1878 and offered for sale in the 1880s. But studies in rodents showed that it could cause bladder cancer when used in huge amounts, so some people were wary of it.

Cyclamate, aspartame, and sucralose became popular in the 1960s and 1970s. Then it was discovered that huge amounts of cyclamate produced bladder cancer in rodents, and in 1970 it was banned in the United States. It is still sold in Canada. Both aspartame and sucralose are still on the market in the United States.

Aspartame was controversial, with internet groups claiming all sorts of horrid side effects, although the FDA said it was safe. In 2002 a related sweetener, neotame, was approved.

Another sweetener, acesulfame K, had a slightly bitter taste and was primarily used mixed with other sweeteners.

Today there are a myriad of artificial sweeteners. Stevia, which comes from a South American plant, has been used there for more than 1500 years. One can use the whole leaves, and one summer summer I grew stevia and used some of the leaves, but some people complain of a licorice flavor. The whole or ground leaves have not been certified by the FDA as GRAS (generally recognized as safe) for food products, although they approved it as a supplement..

However, companies have also isolated the sweet compounds from the stevia leaf, mostly one called rebA, or rebaudioside A. These purified compounds have been FDA approved for use in food. RebA can have a bitter taste if one uses too much.

All of these sweeteners are vastly sweeter than table sugar, or sucrose. For example, saccharin is 200 times sweeter, and neotame is more than 7000 times sweeter than sucrose. This means one has to use tiny amount, difficult to measure. And for this reason many companies cut the sweetness of the compounds with substances like maltodextrin. Some even use glucose. When one is on a low-carb diet, the addition of these bulking agents is problematic.

Another problem with these compounds is that because you need so little of them, they won't reduce the freezing point of frozen desserts as sucrose does. So if you try to make ice cream with saccharin or stevia, it will become rock hard when you put it in the freezer. Fran McCullough in her excellent book The Low Carb Cookbook, published in 1997, has several pages devoted too making ice cream that won't turn into icebergs. None of the suggestions like using alcohol or gelatin worked for me,

But today we have more options, with granular sweeteners that are measured just like table sugar. A popular combination is erythritol combined with a sweeter compound.

Erythritol is a sugar alcohol, but unlike sorbitol and similar sugar alcohols, it doesn't cause gas. This is because it is absorbed into the bloodstream and excreted in the urine rather than going down the intestinal tract to be fermented in the colon to produce gas. It's not quite as sweet as sucrose, so most products combine it with one of the supersweet substance mentioned above.

One popular granular sweetener is Truvia, which consists of erythritol and stevia. Another one combines erythritol and lo han guo, which comes from a southeast Asian plant. Like RebA, the extract has been clasified GRAS. A third, Swerve, combines erythritol and "oligosaccharides." They all seem to contain "natural flavorings," without saying what they are.

All three of these products are now available at my local supermarket.

Two new granular sugars have also come on the market. These are allulose and tagatose. Both are isomers of fructose. An isomer is a compound with the same chemical formula but with a slightly different arrangement of atoms so the enzymes that process them may not recognize them.

Allulose is now available at my supermarket, but you can also get it and tagatose online. These product are not cheap. A pound of sucrose costs about 50 cents. A pound of allulose is about $12.

Despite the price, I decided to try the allulose and tagatose. First I tested the effect on BG, using tiny amounts (1 teaspoon) so I wouldn't spike too high with the control (sucrose). Just 1 teaspoon of sucrose made me go up 20 points on an empty stomach first thing in the morning, and I was back to 80 in an hour. One teaspoon of tagatose made me go up 6 points, as did allulose. As my BG usually goes up after I get up even if I don't eat, it's not clear if this is meter variation, effect of getting up, or the allulose/tagatose, but it doesn't look as if these sugars have a big effect. I don't want to test larger amounts.

I didn't test Truvia or Swerve.

Then I made some ice cream. Eureka! The ice cream was delicious and didn't get rock hard in the freezer. Then I made some crustless cheesecake. Same thing. At last, despite the price, we can occasionally have a traditional dessert with very little effect on blood glucose levels.

Today liquid sweeteners are also more easily available. I didn't use to buy sucralose at the grocery store because of the carby bulking agents it contained. A liquid version was available online, but not at my grocery store. Now the local grocery store carries both liquid sucralose (Splenda Zero) and a stevia version (also Splenda Zero but in a green bottle). Sweet Leaf has offered liquid stevia for some time. Of course the liquids contain preservatives, so if you're sensitive to those, this wouldn't be an answer.

Who knows what new products will emerge in the future or what horrendous side effects will be attributed to the existing sweeteners. Ideally, it would be good to not eat anything sweet so one would lose the taste for sugars. But this isn't an ideal world, and I do like whole-milk yogurt with some flavoring and some sweetener. At least we now have more choice.

Odd Logic about Milk

A study presented at ESC Congress 2018 in Munich has concluded that current dietary guidelines are wrong. With the exception of milk, they said there's no relation between dairy consumption and heart disease, and in fact dairy protects against both total mortality and mortality from cerebrovascular causes.

But what is really odd is the final sentence of the press release (the results of the meta-analysis haven't been published yet).

"And given the evidence that milk increases the risk of CHD, it is advisable to drink fat-free or low-fat milk." Huh? A complex food increases the risk of CHD and the authors assume it's the fat in the milk that is causing the problem?

This is an example of researchers having a preconceived notion and then interpreting their results accordingly. They're assuming fat is bad, and thus if milk has deleterious results, it must be because of the fat. This is despite the fact that cheese, which has more fat and less lactose than milk, is protective.

It's faulty logic like this, as well as reliance on inaccurate Food Frequency Questionnaires,  that has made me ignore most nutritional studies.

Monday, August 6, 2018

Self-Monitoring Saves Money in Finland

"Physicians continue to recommend routine self-monitoring of blood glucose for patients with non-insulin treated type 2 diabetes, in spite of its lack of effectiveness (italics added), because they believe it drives the lifestyle changes needed to improve glycemic control." This is from a recent press release from the American Academy of Family Physicians.

This suggests that the "lack of effectiveness" is a fact, not their opinion, despite the fact that they go on to say that there are both proponents and opponents of self-monitoring of blood glucose (SMBG).

I've discussed this before here  and here. Basically, SMBG does little good if patients are given a meter and told to test once a day, usually fasting or if they're told to test more often, usually before meals but not after eating but they're not told what to do with the results.

 Motivated patients have used their meters to determine which foods make their blood glucose (BG) levels increase the most, and they then eliminate these foods or greatly reduce their consumption. When they do, they find great improvement in their measures of control such as the hemoglobin A1c test. However, such success stories are annecdotal, not formal studies.

One common criticism of SMBG is the cost. Thus it is encouraging to see a Finnish study showing that SMBG along with an electronic feedback system reduced total costs by almost 60%. The study was done in a rural area, and the researchers said that reducing travel costs contributed about 20% to the total savings. So the combination of SMBG and electronic feedback reduced total costs about 40%.

The travel costs are the focus of this article, so there's no discusion of the SMBG or the electronic feedback. Nevertheless, it's encouraging to see that some health care systems recognize the importance of SMBG in treating people with type 2 diabetes.